This gene shares similarity with the mouse Dhm1 and theyeast dhp1 gene. The yeast gene is involved in homologousrecombination and RNA metabolism, such as RNA synthesis and RNAtrafficking. Complementation studies show that Dhm1 has a similarfunction in mouse as dhp1. The function of the human gene has notyet been determined. Transcript variants encoding differentisoforms have been noted for this gene; however, their full-lengthnature is not known.
Titration of the XRN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 48-76 from the human protein was used as the immunogen for this XRN2 antibody.
Aliquot the XRN2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
