ZAK/MLKLAK is a member of the MAPKKK family of signal transduction molecules.It possesses an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein formshomodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity.

Titration of the ZAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 271-300 from the human protein was used as the immunogen for this ZAK antibody.

Aliquot the ZAK antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.