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Western Blot 样品制备方案 | NSJ 生物试剂,LKT/MONASTROL/M5752/5 mg
来自 : 发布时间:2025-06-15
Product ID M5752Cas No. 254753-54-3Purity ≥95%
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References

Description

Monastrol is a pyrimidine derivative inhibitor of kinesin Eg5 that inhibits ATPase activity and bipolar spindle formation. Monastrol exhibits anticancer activity, activating the spindle checkpoint but also inducing mitotic arrest and apoptosis in HeLa cells. Monastrol also induces dendrite growth and axonal shortening in neurons.

Product Info

Cas No.PurityFormulaFormula Wt.Chemical NameIUPAC NameMelting PointSolubilityAppearance

254753-54-3

≥95%

C14H16N2O3S

292.35

1,2,3,4-Tetra- hydro-4-(3-Hydroxyphenyl)- 6-methyl-2-thioxo-5-pyrimidinecarboxylic acid ethyl ester

ethyl(4S)-4-(3-hydroxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate

184-186°C (lit.)

Soluble in DMSO (100mg/mL).

White to light yellow solid

Shipping and Storage

Store TempShip Temp

4°C

Ambient

Downloads

Info Sheet

M5752 Info Sheet PDF

References

Chin GM, Herbst R. Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint. Mol Cancer Ther. 2006 Oct;5(10):2580-91. PMID: 17041103.

Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006 Feb 27;6:2. PMID: 16504166.

Yoon SY, Choi JE, Huh JW, et al. Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures. Cell Motil Cytoskeleton. 2005 Apr;60(4):181-90. PMID: 15751098.

Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol. 2002 Sep;9(9):989-96. PMID: 12323373.

本文链接: http://nsj.immuno-online.com/view-1551505825.html

发布于 : 2025-06-15 阅读()